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The core mission of the IRSF is to fund research for treatments and a cure for Rett syndrome while enhancing the overall quality of life for those living with Rett syndrome by providing information, programs, and services. In 1983, a small dedicated group of parents whose children had Rett syndrome formed the first non-profit to focus exclusively on Rett syndrome – International Rett Syndrome Association (IRSA). In 2007, IRSA and Rett Syndrome Research Foundation (RSRF) consolidated resources to better serve families and maximize research investments toward a cure. The International Rett Syndrome Foundation (IRSF) emerged with a mission to accelerate research and empower families that builds upon these foundations’ pioneering work toward care and cure. We are walking this journey with you. IRSF is comprised of parents and friends of those diagnosed with Rett syndrome. We are dedicated to empowering families with the latest medical information, offering meaningful support and resources, and advocating for all those living with Rett syndrome. Our strategy is simple but powerful: improve care today and create treatments for tomorrow. IRSF is committed to a full-spectrum approach, providing solutions for everyone living with Rett syndrome. We do this by investing in innovative research, working to build a robust treatment pipeline, and removing barriers to ensure clinical trial success.

The Huntington's Disease Society of America is the premier nonprofit organization dedicated to improving the lives of everyone affected by Huntington’s disease. From community services and education to advocacy and research, HDSA is the world’s leader in providing help for today and hope for tomorrow for people with Huntington’s disease and their families. HDSA's network of chapters, affiliates, HDSA Centers of Excellence, social workers and support groups provides a seamless connection for help, education and outreach to HD families and health care professionals across the United States.

Guide Dogs for the Blind provides enhanced mobility to qualified individuals through partnership with dogs whose unique skills are developed and nurtured by dedicated volunteers and a professional staff. Established in 1942, Guide Dogs for the Blind continues its dedication to quality student training services and extensive follow-up support for graduates. Our programs are made possible through the teamwork of staff, volunteers and generous donors. Services are provided to students from the United States and Canada at no cost to them.

The Pediatric Brain Tumor Foundation works to eliminate the challenges of childhood brain tumors. Our vision is a cure for childhood brain tumors.

Founded in 1910, the Center for Hearing and Communication is the oldest and largest nonprofit organization providing comprehensive hearing rehabilitation and social services programs for individuals who are deaf or have hearing loss. With locations in New York and Florida, we continue to expand and enhance services for the deal/hard of hearing community, while adhering to our mission by providing services regardless of age, ability to pay, or mode of communication.

Wellness in the Schools is a national non-profit that teaches kids healthy habits to learn and live better. We partner with public schools to provide nutrition and fitness education, healthy scratch-cooked meals and active recess periods. Our approach improves student outcomes and drives systemic, long-term change, shifting school cultures.

From the website: "We are the only Hong Kong charity dedicated to gynaecological cancers. The Karen Leung Foundation’s mission is to save lives by reducing the impact of gynaecological cancers in Hong Kong. We envision a world where women have every opportunity to live healthy and fulfilling lives free from gynaecological cancers."

The Hendren Project (THP) mission is to provide sponsor-supported digital resources that enable a global pediatric surgical community to help one another better serve children with complex surgical issues throughout their lives. The digital resources are provided to THP members without charge through the THP website.

Founded in 1914, the American Sexual Health Association (ASHA) promotes the sexual health of individuals, families and communities by advocating sound policies and practices and educating the public, professionals and policy makers, in order to foster healthy behaviors and relationships and prevent adverse sexual health outcomes.

METAvivor is dedicated to the specific fight of women and men living with stage 4 metastatic breast cancer. At the time of METAvivor’s founding, no organization was dedicated to funding research for the disease and no patient groups were speaking out about the dearth of stage 4 cancer research. While more and more people have taken up the cry for more stage 4 research, METAvivor remains the sole US organization dedicated to awarding annual stage 4 breast cancer research.

WALKSacramento works with transportation and land use planners, elected officials and community groups to create safe, walkable environments for all citizens and particularly for children, seniors, the disabled and low-income individuals. WALKSacramento works to incorporate pedestrian access into transportation and development decisions, to increase funding for pedestrian infrastructure, and to adopt and implement pedestrian master plans for local communities.

For more than 20 years, the Clinton Foundation has transformed philanthropy — running programs that develop leaders and accelerate solutions to the world’s most pressing challenges. Under the leadership of President Clinton, Secretary Clinton, and Chelsea Clinton, our unique approach prioritizes solutions over ideology — bringing people together in the spirit of collaboration and pragmatic problem-solving for a brighter future. Programs founded by the Clinton Foundation since its inception reflect our shared commitment to “putting people first” — the practice of focusing on how a proposed policy, program, or partnership can directly affect a person’s life and make a lasting impact.